TxFlow™ Go
Automated TFF System for low-volume and scalable processing
Affordable | 0.5 mL – 2 L | Go-to TFF system | Learn in < 20 minutes
TxFlow™ Go automates concentration and constant-volume diafiltration for low-volume samples with minimal hold-up volume. Set your target concentration or diafiltration volume, the system monitors your run, and automatically stops at completion.
TxFlow™ Go is purposely designed for routine TFF applications in research and sample treatment. For GMP applications, contact us about GMP packages.
Simple by design. Fast by intent. We engineered TxFlow™ Go to remove unnecessary complexity from TFF. By solving the hard problems — automation, hold-up volume, and setup — we make routine TFF faster, more reproducible, and accessible, so you can focus on your science.
Key Features
- Automated CVDF： Set targets, walk away, get reproducible results
- Weight-based endpoint detection： Eliminates operator variability
- Ultra-low hold-up volume： Less than 0.5 mL recoverable with Tanda flow paths
- ReadyPath™ consumables： Pre-assembled flow paths for 5-minute setup
- Scalable process parameters： Simple process transfer to larger systems
Specifications
| Operating Volume | 0.5 mL – 500 mL |
| Minimum Hold-up Volume | <0.3 mL (achievable with Tanda flow path) |
| Flow Rate Range | 0.1 – 200 mL/min |
| Pressure Rating | Up to 30 psi |
| Tubing Options | Size #13, #14, #16, #19 |
| Dimensions | 12" × 10" × 8" (W × D × H) |
| Lead Time | Ships within 2–3 weeks |
What's Included
- TxFlow™ Go control unit
- Starter pack of ReadyPath™ flow paths
- Installation support and operator training
- 12-month warranty (parts and labor)
ReadyPath™ Consumables
ReadyPath™ consumables are pre-assembled, ready-to-run flow paths that eliminate manual tubing assembly and operator variability. Installation takes less than five minutes — no fitting selection, no custom builds, no guesswork. Every TxFlow™ Go ships with a sample flow path pack.
TxPath™ Flow Path HF-5
Small filter down to 5 cm² area
for 0.5–50 mL volume
ReadyPath™ HF-20
20 cm² hollow fiber
5–200 mL volume
ReadyPath™ FS-100
100 cm² flat sheet
100–1,000 mL volume
Custom Configurations
Contact us for specific membrane types, MWCOs, and sizes
Compatible with most hollow fiber and flat sheet membranes from 10 kDa to 750 kDa MWCO. Contact us for pricing and availability.
Custom Integrated Systems
Pilot & Production-Scale Solutions
Decades of experience | Many applications
When your application demands more than benchtop scale, we design and build integrated filtration systems matched to your specific process requirements. Our team has decades of experience engineering custom bioprocessing solutions — including systems that delivered COVID vaccine filtration under Project Warp Speed.
What We Build
- Perfusion systems： High-density cell culture with continuous media exchange
- Pilot-scale TFF： 500 mL – 10 L+ processing with full automation
- Multi-stage filtration： Integrated clarification, concentration, and diafiltration
- Specialized configurations： Ceramic membranes, reusable systems, harsh chemical compatibility
How It Works
- Consultation： We discuss your process requirements and constraints
- Engineering： Our team designs a system matched to your specific application
- Build & Test： We build, test, and validate before delivery
- Installation： On-site installation, training, and process support
Why Work With Us
- 80+ years combined filtration and bioprocess engineering experience
- Proven delivery on critical programs, including COVID-19 mRNA LNP large-scale manufacturing
- Engineer-led, customer-centric development from concept to installation
Integrated Flow Path Systems
Low-Volume Tangential Flow Filtration
Hollow fiber filter | Tubing | Process vessel | Optional inline pressure sensor
A complete, ready-to-run single-use flow path built for gentle, low-shear concentration, diafiltration and buffer exchange — for nanomedicines, exosomes, lipid nanoparticles (LNP), viral vectors, mRNA and proteins. Every component is also available separately.
The flow path integrates every fluid-contact component — hollow fiber filter, pre-connected tubing and process/recirculation vessel — into one pre-assembled single-use set, with an optional inline sensor for real-time transmembrane pressure (TMP) monitoring. Feed recirculates tangentially through the fiber lumen while buffer, salts and species below the MWCO pass through the membrane wall as permeate, continuously sweeping the membrane surface for high flux, high recovery and low shear.
Two purpose-built configurations cover the low-volume range: a 10 cm² filter with a 5 mL process vessel, or a 20 cm² filter with a 50 mL reservoir. Hollow fiber filters and pressure sensors are also sold separately, so you can build or extend a flow path to fit your own setup.
Key Advantages
- Ready to run： Filter, tubing and vessel arrive pre-assembled — install, load, start
- Low volume & scalable： Uniform 0.5 mm ID fiber channels protect exosomes, LNPs, viral vectors and shear-sensitive proteins
- Single-use, no carryover： No cleaning validation, no cross-contamination between products
Key Applications
Nanomedicines and drug delivery particles · exosome and extracellular vesicle enrichment · lipid nanoparticles (LNP) · viral vectors (AAV, lentivirus) · mRNA and plasmid DNA · recombinant proteins and antibodies. Suited to concentration, desalting, buffer exchange and gentle handling of high-value samples at research scale.
Key Specifications
| Hollow fiber membrane area | 10 cm² and 20 cm² |
| Membrane MWCO | 100 kD · 300 kD · 500 kD · 750 kD |
| Fiber inner diameter (ID) | 0.5 mm |
| Effective fiber length | 10 cm (10 cm²) · 20 cm (20 cm²) |
| Process vessel | 5 mL (10 cm²) · 50 mL reservoir (20 cm²) |
| Recommended recirculation rate | 21–31 mL/min |
| Inline pressure sensor | Optional · single-use · one SKU (PT-01) |
| Configuration | Complete flow path, or components ordered separately |
Designed for seamless use with the TxFlow™ Go filtration system and with standard laboratory TFF pumps.
Ordering Information
What's in the Flow Path
| Hollow fiber filter | Tubing set | Process vessel | Pressure sensor |
|---|---|---|---|
| 10 or 20 cm² · MWCO of choice | Pre-assembled, low hold-up volume | 5 mL (10 cm²) / 50 mL (20 cm²) | Optional (-PT) · PT-01 |
Flow Path Systems
| Part number | MWCO | Membrane area | Vessel volume | Pressure sensor |
|---|---|---|---|---|
| RP-R10-Exxx-05-NR | 100–750 kD | 10 cm² | 5 mL | No |
| RP-R10-Exxx-05-NR-PT | 100–750 kD | 10 cm² | 5 mL | Yes (PT-01) |
| RP-R20-Exxx-05-NR | 100–750 kD | 20 cm² | 50 mL | No |
| RP-R20-Exxx-05-NR-PT | 100–750 kD | 20 cm² | 50 mL | Yes (PT-01) |
Replace xxx with the MWCO (100 / 300 / 500 / 750). The RP- prefix marks a flow path assembly; the -PT suffix adds the inline pressure sensor.
Filters — Sold Separately
A bundle of fine hollow fibers with a 0.5 mm inner diameter gives uniform flow channels, gentle shear and low dead volume. Feed travels through the fiber lumen while permeate passes through the fiber wall. This is the preferred format for shear-sensitive biologics — viral vectors, exosomes and gentle protein concentration in particular. Order it standalone or as part of a complete flow path system.
| Part number | MWCO | Membrane area | Fiber ID | Length | Recommended flow rate |
|---|---|---|---|---|---|
| R10-E100-05-NR | 100 kD | 10 cm² | 0.5 mm | 10 cm | 21–31 mL/min |
| R10-E300-05-NR | 300 kD | 10 cm² | 0.5 mm | 10 cm | 21–31 mL/min |
| R10-E500-05-NR | 500 kD | 10 cm² | 0.5 mm | 10 cm | 21–31 mL/min |
| R10-E750-05-NR | 750 kD | 10 cm² | 0.5 mm | 10 cm | 21–31 mL/min |
| R20-E100-05-NR | 100 kD | 20 cm² | 0.5 mm | 20 cm | 21–31 mL/min |
| R20-E300-05-NR | 300 kD | 20 cm² | 0.5 mm | 20 cm | 21–31 mL/min |
| R20-E500-05-NR | 500 kD | 20 cm² | 0.5 mm | 20 cm | 21–31 mL/min |
| R20-E750-05-NR | 750 kD | 20 cm² | 0.5 mm | 20 cm | 21–31 mL/min |
Every MWCO shares the same dimensions and flow characteristics — change the cut-off without changing the setup.
Inline Pressure Sensor
The single-use PT-01 sensor fits every flow path system and monitors transmembrane pressure (TMP) inline. It ships with any -PT assembly and can also be ordered on its own to add pressure monitoring to an existing flow path. One SKU covers every filter size and MWCO — nothing else to select or configure.
| Part number | Description |
|---|---|
| PT-01 | Inline single-use pressure sensor — the only SKU; included in every -PT flow path system |
How Part Numbers Work
| Example | Meaning |
|---|---|
| RP-R10-E100-05-NR | Flow path system built on the R10-E100-05-NR filter (10 cm² · 100 kD), without pressure sensor |
| RP-R20-E300-05-NR-PT | Flow path system built on the R20-E300-05-NR filter (20 cm² · 300 kD), with the PT-01 pressure sensor |
| R20-E300-05-NR | Standalone hollow fiber filter · 20 cm² / 20 cm · 300 kD · 0.5 mm ID · NR series |
RP- = flow path assembly · R{area} = membrane area / effective length (10 or 20) · E{MWCO} = cut-off in kD · 05 = 0.5 mm fiber ID · NR = product series · -PT = includes the PT-01 sensor.
Process Vessels & Accessories
| Part number | Description | Volume | Used with |
|---|---|---|---|
| PC-05 | Process vessel / conical tube | 5 mL | 10 cm² flow path |
| PC-10 | Process vessel | 10 mL | Standalone |
| PC-15 | Process vessel | 15 mL | Standalone |
| PC-50 | Reservoir | 50 mL | 20 cm² flow path |
| PT-01 | Inline pressure sensor (single SKU) | Single-use | Any flow path / -PT |
For a quote or a sample, tell us your target sample type, starting volume and MWCO requirement — we'll recommend a complete flow path system or just the components you need.